Our bodies are thought to produce endocannabinoids by the billions every day. “We always thought the ‘runner’s high’ was due to the release of dopamine and endorphins. But now we know the euphoria is also from an endocannabinoid called anandamide,” its name derived from the Sanskrit word for bliss, says Joseph Maroon, MD, clinical professor and vice chairman of neurosurgery at the University of Pittsburgh Medical Center. We produce these natural chemicals all day, but they fade quickly because enzymes pop up to destroy them. That’s where CBD comes in: By blocking these enzymes, CBD allows the beneficial compounds to linger.
The tincture is available in three strengths: 500mg, 1,000mg, and 3,000mg. Prices range from $0.04 to $0.07 per mg, depending on the concentration, which makes the tincture very low-priced compared to oils from most competing brands. Medterra also offers a 30-day satisfaction guarantee and will issue full refunds for all returns. In addition to the tincture, Medterra also offers CBD capsules in 25mg and 50mg concentrations.
The major problem with CBD bottles on the open market is that in most cases they will contain levels of THC which are higher than the amount legally allowed to sell. This means that in most states (with only a few exceptions such as California, Colorado and Oregon), THC is currently legally available only as Medical Cannabis, and should be sold only by legit dispensaries that have received proper licensing from the state.
CBD works by attaching itself to specific receptors of the body’s own endocannabinoid system. The human body is known to produce cannabinoids of its own, which affect the cannabinoid receptors CB1 and CB2. The CB1 receptors are generally found in the brain, and deal with pain, mood and emotions, movement, appetite, among others. THC acts upon the CB1 receptors. Meanwhile, CB2 receptors are more commonly found throughout the immune system, affecting inflammation and thus pain. CBD is thought to act upon these receptors, by influencing the body to produce its own cannabinoids in order to rebalance itself.
As with a fermented food like kombucha, slight natural variations are normal and to be expected in a product such as CBD oil because it is made from living plants. Changes in the weather, soil, and water can all impact the biology of the source material. While we verify Certificates of Analysis (and take many other criteria into consideration during our review process), even the most reputable five-star companies have no way to control for every variable in this organic process.
CBD may be best known for its relaxing, calming effects. CBD reduces autonomic arousal, having the inverse effect of THC on the body. CBD’s anti-anxiety effect is why many in the cannabis community talk about how CBD relieves paranoia, although that is not scientifically proven yet. CBD is also known for its anti-nausea and pain relieving effects. It really depends on why your body’s specific needs and the quantity in which you take CBD.
As with a fermented food like kombucha, slight natural variations are normal and to be expected in a product such as CBD oil because it is made from living plants. Changes in the weather, soil, and water can all impact the biology of the source material. While we verify Certificates of Analysis (and take many other criteria into consideration during our review process), even the most reputable five-star companies have no way to control for every variable in this organic process.
Although I’m no physician, and am not qualified to recommend any drugs for any specific medical purposes, and you should consult your doctor when considering the consumption of anything that may be medicinal: If you’re looking to experiment with CBD products, you might consider looking for CBD products that are “whole plant” extract based from very high CBD cultivars. If you’re in a State that has a legal Cannabis system, you may also find more therapeutic benefits from non-hemp derived CBD products. 

Unlike THC, CBD will not make you high. That said, this doesn’t mean CBD is not at all psychoactive, as many assert, says Jahan Marcu, PhD, director of experimental pharmacology and behavior at the International Research Center on Cannabis and Mental Health in New York City: “CBD does change cognition. It affects mood, which is why people take it for anxiety. And some find that it makes them more alert.”
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
Give it some more time… truly. You’ve also increased your dosage pretty quickly in a 3 week period. More is NOT better in CBD land… that’s hard to remember. Give your body time to allow it to work. I’m as skeptical as they come, but my anxiety is far less than 1/2. My overall mood and demeanor is entirely different. My meds are gone, or decreased. Time is the key. Patience is the key. It’s a tricky process, but I’m proof that it works!!
I suffer fr migraines. Currently having Botox injections every three months for the last three years. This has helped went fr 24 to 30 migraines a month to 6 to 8 , now I’m back up to 14 to 20 a month.  My doctor thought CBD oil might help. I have also started having anxiety attacks for a year now.  I’m really confused with the dosages.  Any thoughts would b helpful
I have had several neurological conditions like Bells Palsy three times, double vision, paralysis of left side of tongue. I have a lot of relief whenever I have pain by taking an inflamattory drug etoshine90 mg. Presently I have started taking Steroids for my facial palsy. The various pains I was having on the left side of neck, below the left ear, dizziness, pain around the head have subsided immidiately after the first dose of prendisolone 60 mg.
I’ve just started today with 250mg cbd oil.  I’m starting low to see what happens.  I’ve nerve damage across buttocks from a laminectomy.  I’ve not been able to sit for 5 years. I’ve recently started with a muscle spasm in my left buttock and the muscle above is painful. It is only the first day, also tried a cbd night time tea as well.  Do change in muscle pain so tight on my left hand side.  How long before felt it starting to work please.  I’m trying not to expect changes straightaway.  I also take 1100mg gabapentin and 30mg amitriptyline and I hate both of them – they both can cause muscle tightness affecting the nerve.  Thank you Lyn
I am a father of six boys and have two combat tours under my belt with the Army Infantry. I suffered for years with anxiety, depression ,knee and back pain, until this. Plus CBD oil , gold has changed everything, I have used approximately 7 drops twice daily for almost a year now. I decided to try CBD oil after a trip to the ER for heart palpitations and severe anxiety attack, that I thought was a heart attack but after the ER told me my heart was fine and after seeing a cardiologist and him also clearing me, I suffered from a lump under my rib cage that almost felt like someone was squeezing my heart all day, every day until I started the CBD oil drops. It took me over7 mo ths to feel normal again but slowly , using CBD oil every day, my symptoms have almost completely went away. Today I have very mild anxiety and the stress is bearable., I feel much more relaxed than I did for almost 13 years after exiting the military. If you suffer from mild knee or back pain, moderate to severe anxiety or are prone to lots of stress, this is your saving Grace. This stuff did what Drs and Cardiologists couldn’t do! Twice a day, when you get up and just before bed. Feel better every day and it’s been a year…..still getting better.
Secondly, keep in mind that pure hemp oil does not taste good to many. Each harvest renders slightly different flavors because the flavor and aroma come from compounds within the hemp plant called terpenes. Just like cannabinoids, you don’t know exactly which terpenes have developed in the plant until the oil has been extracted and tested. This makes it difficult to guarantee how each batch will taste.

Cost is another consideration. Most CBD oils are sold in concentrations of 300 to 750 mg, although this may range from less than 100 mg to more than 2,000. A good indicator of price-point is the cost per milligram. Low-cost CBD oils usually fall between five and 10 cents per mg; mid-range prices are 11 to 15 cents per mg; and higher-end oils cost 16 cents per mg or higher. Given these varying per-milligram costs, a bottle of CBD oil may be priced anywhere from $10 or less to $150 or more.
I have been taking full spectrum Hemp CBD oil (1000mg)(Green Gold CBD) sublingually for two months, a daily dosage of 50mg. I had no noticeable side effects. The other morning I took 100 mg to see if it changed anything with respect to some back pain I was experiencing. At lunch I had explosive diarrhea which lasted for several hours. It went away over night. Today, I went online and learned that 10% of CBD get similar problems.
This is apparently not typical, but I have met a few other “bad back people taking opioids” with similar complaints.  I have researched that CBD shuts down certain liver enzymes (like CYP2D6 and other CYP450 family enzymes) that allow the liver to process Tramadol and many other meds to the metabolite form that actually relieves pain.  So for my particular chemistry CBD was essentially blocking the pain relief from the Tramadol.
Success stories like Oliver’s are everywhere, but there’s not a lot of data to back up those results. That’s because CBD comes from cannabis and, like nearly all other parts of the plant, is categorized by the Drug Enforcement Agency (DEA) as a Schedule 1 drug—the most restrictive classification. (Others on that list: heroin, Ecstasy, and peyote.) This classification, which cannabis advocates have tried for years to change, keeps cannabis-derived products, including CBD, from being properly studied in the U.S.
It makes no sense to me that something that helps with anxiety has an irritability side effect – as a lot of my anxiety is co-mingled naturally with irritability. Further, I have noticed none of these side effects, given that if you become fatigued or sleepy, you adjust dose the next day. So I don’t call that a side effect – rather – an effect of taking too much.
Even though high-strength CBD oils are more expensive than lower concentrates, they work out to be more cost-effective and longer-lasting because you’ll need fewer drops to obtain the same effect. For example, a single drop of Love Hemp’s 40% CBD oil contains 20mg of CBD, that is 4 times more than a 10% tincture, which provides just 5mg per drop. If you’re looking to take a high dose, stronger concentrates will also make it easier to achieve your desired dose (fewer drops to count!).
I am approaching three weeks of being on CBD gold drops and just purchased the applicator version. I also bought the balm to rub on for shoulder pain. The first week I thought maybe I was wanting to believe in it so much that it was working, that maybe it was just that. I simply couldnt believe that it would work after all the doctors Id been to. Was recently told I would need to be on weekly shots for psoriatic arthritis and fibromyalgia. Have had two wrist surgeries and was looking at a shoulder and elbow surgery in my future. Have celiac disease and chronic pancreatitis too. Since taking this, I have had no joint or muscle pain! Happier because can do things! No anxiety being concerned about having to go places with pain. I don’t have the pain. Some days will have an aches, but can handle. Opioids never worked for me, so told doctors not to give me. I felt at a loss and decided one day that I would try CBD oil. By the second week, I was convinced! Im doing yard work and sleeping again! Im feeling normal! So thankful! I take it daily. Right now a dropper full of 5mg but plan on trying the applicator gold.
Because I never go downtown, I had to stop for a latte at my favorite coffee shop—and a second CBD pick-me-up. By the time I stepped into the crowded Indie Beauty Expo, I felt calm and happy. As an introvert, I usually have a hard time making small talk at events. But post-CBD oil, I felt comfortable enough to chat up a storm with every person I met! Three hours later I dragged myself out of the huge exposition and made it to my meditation class, where I took another dropper of CBD oil. Although I really love meditating, I find it particularly challenging to get into the “zone” after a long day at work. Not so much after taking some CBD—it was easy to calm my mind and tune into my breath, despite how fast-paced my day had been.

There are many websites claiming that their CBD oils can cure everything. This is not true! Reputable companies extract their CBD oils from specific strains, and remember that each strain has its own unique CBD/THC ratios. Also, some are Sativa and some are Indica; therefore, the oil extracts may work better on some conditions and some individuals than on others. Always read the fine print, and if a company offers a list of medical conditions the CBD oil treats best, just know that it’s completely bogus.


Because I never go downtown, I had to stop for a latte at my favorite coffee shop—and a second CBD pick-me-up. By the time I stepped into the crowded Indie Beauty Expo, I felt calm and happy. As an introvert, I usually have a hard time making small talk at events. But post-CBD oil, I felt comfortable enough to chat up a storm with every person I met! Three hours later I dragged myself out of the huge exposition and made it to my meditation class, where I took another dropper of CBD oil. Although I really love meditating, I find it particularly challenging to get into the “zone” after a long day at work. Not so much after taking some CBD—it was easy to calm my mind and tune into my breath, despite how fast-paced my day had been.


There are many websites claiming that their CBD oils can cure everything. This is not true! Reputable companies extract their CBD oils from specific strains, and remember that each strain has its own unique CBD/THC ratios. Also, some are Sativa and some are Indica; therefore, the oil extracts may work better on some conditions and some individuals than on others. Always read the fine print, and if a company offers a list of medical conditions the CBD oil treats best, just know that it’s completely bogus.
Connie, I was happy to read your comment & recommendation. I have found CBD to be extremely helpful also. My main issue with it is that I have bought from 3 different companies, and now I just bought Plus CBD because it was the only brand available in my home town, and I didn’t want to wait for the mail order. Unfortunately, in my inexperience, I thought I I was buying a high potency, and now find it is LOW, and very expensive for that. However, my story sounds very similar to yours, cancer, chemo killed my veins, used Norco for years, and now my body has VERY poor muscle tone. I will continue on, though, and wanted you to know that I was very encouraged by your inspirational story. I saw my primary MD today, and she was excited about my progress & success with CBD, especially since I have discontinued 3 medications. Now, to be able to get in good shape, and lose weight like you have also. THANK YOU!
Thank you. I am 81 and started the CBD drops night and morning. I sleep better and no longer suffer the excruciating pain from diverticulitis. I saw somewhere that for my asthma I need the THC so got some (totally illegal here in South Africa). I think it is helping. The diagnosis of COPD was made some years ago and as a health psychologist I do all I can to remain healthy for my 97th birthday!! (Both my grandmother and greatgrandmother did so I believe I will too).
Kent, My mother has suffered from severe migraines since she was a child. Six weeks ago, she received the hemp oil tincture (I do not know what dosage). She does not take it daily. She rubs a drop or two on her temples at the start of a migraine. The drops worked more effectively for her than her medication did, and now that is all she uses. Hope this helps.
As of 2017, the words “CBD oil for Sale”, or just simply “CBD for sale” have been two of the most popular phrases written into Google. It seems as if everyone is looking for a great deal online, or a way to find CBD oils on sale. The thing is, you don’t have to look very far. The increase in demand over the last couple of years has driven most sellers and CBD oil companies to reduce prices and offer their products at discount rates.
When extracting THC from the cannabis plant, it’s not easy to separate the THC from the mixture. This requires skill, expertise, and technology. Some shady brands create DIY CBD oils by using dangerous solvents, and then try to sell their products online. They sell them at extremely low prices, looking to make a quick buck. Before purchasing, always make sure that the CBD oil you are looking at has no psychoactive effects, and makes sure that it has been extracted with CO2 techniques as this ensures that no dangerous chemical solvents were used. And remember that THC is illegal in most states, so you don’t want to get on the wrong side of the law.
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