A report from the American Academy of Pediatrics (AAP) published in the journal Pediatrics cautions pregnant women and nursing mothers to avoid marijuana use due to possible adverse developmental effects to their baby. In a study reviewed for the report, short-term exposure to CBD was found to increase the permeability of the placental barrier, potentially placing the fetus at risk from certain substances.
“In all of the tests, the isolated CBD was ineffective both before and after a certain dosage, while the effectiveness of the full-spectrum solution continued to increase as higher doses were administered. The results all indicate that CBD is only effective against swelling and pain at a certain dose, and that cannabis solutions containing a full range of cannabinoids will continue to provide corresponding effects as the dosage is increased.”
Vaping CBD is regarded by many to be the best ecological and healthy way to administer, and as such, this has led to an increase in the demand for CBD isolate. This form of CBD is different from full-spectrum CBD extract in that it only contains CBD and none of the other cannabinoids, terpenes, or healthy fatty acids that commonly result from the whole plant extraction process.

“In all of the tests, the isolated CBD was ineffective both before and after a certain dosage, while the effectiveness of the full-spectrum solution continued to increase as higher doses were administered. The results all indicate that CBD is only effective against swelling and pain at a certain dose, and that cannabis solutions containing a full range of cannabinoids will continue to provide corresponding effects as the dosage is increased.”
Unfortunately the availability of only CBD isolate medically is a direct consequence of the 1920’s prohibition campaign that outlawed cannabis medications, despite the fact that prior to prohibition cannabis was listed in the United States pharmacopeia as a valuable medication in the treatment of over 100 separate medical conditions. It is still illegal to market THC in cannabis medications despite its known efficacy.
They have loads of positive customer reviews on their website, including recommendations from a prominent UK/EU CBD user Facebook group. Even though Provacan legally does not advertise their CBD oils as having medicinal effects, one customer (by the name of “Seb”),  noted that he/she use the 6% oil for chronic pain, and after 2 weeks was able to cut their prescription meds by almost 50%.
It has proved to be pretty useless at treating anything apart from limited success with Multiple sclerosis (MS)spasticity and even then the results are not impressive. As early as October 2014, NICE published guidance on the management of MS and said that the substantial cost of Sativex “compared to the modest benefit” did not justify its use. Paying for it privately will cost you about £350 a month.
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